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The HALT Fentanyl Act and Impact on Research

The HALT Fentanyl Act recently passed has significant implications for researchers, especially those that are studying fentanyl-related substances (FRS). One of the major impacts from this Act is that it permanently classifies all fentanyl-related substances (FRS) as Schedule I substance under the Controlled Substance Act. 

This means:

  • These substances are considered to have no accepted medical use and a high potential for abuse
  • Researchers must follow strict DEA registration and security protocols to work with them

Impacts on Research - Do you research fentanyl-related substances?

While the law is designed to fight the opioid crisis, it also affects how scientists can study these substances:

  • Tighter Restrictions: Researchers must now follow strict federal rules to study any fentanyl-related compound, including special DEA registration and secure storage.
  • Registration:  Researchers must submit a completed application for registration (or modification of an existing DEA registration) within 90 days of a substance being scheduled under the Act.

If you no long need or studying fentanyl-related substances you should dispose of them as soon as possible by a 
non-retriable method.

To Continue Working with Fentanyl-Related Substances:

Any individual or institution intending to conduct research on fentanyl-related substances that are now classified as Schedule I must apply.

The application must be submitted to the Drug Enforcement Administration (DEA) and include:

  • A detailed research protocol.
  • Security measures for handling Schedule I substances.
  • Justification for the quantities requested.
  • Institutional approvals (e.g., IRB, if applicable).

Once registered, researchers must comply with strict storage, recordkeeping, and reporting requirements. The DEA may inspect facilities to ensure compliance.

DEA - Schedule 1 Controlled Substance for Research Information 

The Controlled Substance Program for Research provides resources for researchers to navigate Schedule 1 Registration process. 

Schedule 1 Registration Resources

Questions email: controlledsubstances@ehs.ucla.edu